Course Description

This is the second course in the Essential Precision Medicine core series that explores the field of genomic and precision medicine. These courses are meant for a lay person (i.e. non-geneticist) who wishes to gain some basic genomic literacy and an understanding of the foundational concepts and vocabulary used in genomic and precision medicine.


What you'll learn

In this brief course (total run time ~40 min) we'll explore the genetic basis of diseases. We’ll focus on two main types of genetic diseases: Classical rare Mendelian (monogenic) diseases and common (polygenic) diseases. We’ll explore characteristics of both types of genetic diseases, break down GWAS studies, and touch on newer polygenic risk scores.

Our courses aim to minimize the jargon and teach precisely what is needed, and not more. If you're looking for a deep understanding of genetics, this isn't the course for you. If you want to be conversational in genomics, are currently working in a field that touches on precision medicine, ready to implement genetic testing in your medical practice, or simply want to understand the value and limits of available genetic tests, you're in the right place!    

After taking this course, you should be able to do the following: 

  • Distinguish features of monogenic vs polygenic diseases 
  • Understand how GWAS work 
  • Discern the different information provided by p values and odds ratios 
  • Appreciate the value and limitations of polygenic risk scores

Instructor

Founder, Precision Medicine Advisors

Jeanette McCarthy, PhD

Jeanette McCarthy is a genome scientist and leading educator in the field of precision medicine. She spent the early part of her career in industry at Millennium Pharmaceuticals before transitioning to academia. She currently holds adjunct faculty positions at Duke University and UCSF and teaches Genomic and Precision Medicine in the UC system and online.

Course curriculum

  • 1

    Welcome

    • Welcome to Genes, Heredity and Disease

  • 2

    Discussion Forum

    • Tell us about yourself

  • 3

    PM 102: Genes, Heredity and Disease Videos

    • Genes, Heredity and Disease: Introduction

    • Mendelian (monogenic) diseases (12:58)

    • Recognizing a mendelian disease/trait (5:17)

    • Multifactorial (polygenic) diseases (11:26)

    • Strength of genetic associations (12:34)

Reviews

5 star rating

Priti Vijayvargiya

5 star rating

fine - maybe it should be Genes, Herdity, Environmental a...

Christine Gorjanc

good

5 star rating

Mark Calarco

5 star rating

Genes, Heredity, Disease

Shailavi Jain

Again, excellent presentation of slides and material. Discussion of comparison of Mendelian vs Multifactorial Dx, genetic association, odds ratio and more.

Again, excellent presentation of slides and material. Discussion of comparison of Mendelian vs Multifactorial Dx, genetic association, odds ratio and more.

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5 star rating

Making it clear

Ken Knight

Super course that bundles complex theory into clear segments

Super course that bundles complex theory into clear segments

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5 star rating

PM 102: Genes, Heredity, and Disease

Alexa Bancroft

This course was straight-forward and gave a concise review of statistical significance vs. clinical significance.

This course was straight-forward and gave a concise review of statistical significance vs. clinical significance.

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5 star rating

perfect

jirached suksuperm

give me clear picture about basic of clinical genetic in short time

give me clear picture about basic of clinical genetic in short time

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5 star rating

educational

Maegen Hahn

educational material.

educational material.

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5 star rating

Mike Thompson

5 star rating

Excellent course

Fátima Rodríguez Álvarez

I want to congratulate the creators and organizers of the course

I want to congratulate the creators and organizers of the course

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4 star rating

Lynn Deng